How to Choose the Best Centrifuge for Your Laboratory: A Complete Buying Guide

Introduction

Selecting the right centrifuge can be challenging—especially when you’re faced with a wide range of models, speeds, and rotor types. Whether you're working in clinical diagnostics, academic research, molecular biology, or pharmaceuticals, the centrifuge you choose must suit your samples, throughput, and accuracy requirements.

This guide is designed to help you identify what centrifuge to buy, based on your lab’s size, sample type, and application needs. If you’re searching for the best centrifuge for laboratory use, this is the resource you need.

1. Start With Your Application

Your application determines nearly every aspect of the centrifuge you'll need. Ask:

• Are you working with blood, cells, proteins, or DNA?

• Do you require temperature control?

• Do you process samples in microtubes, 15 mL conicals, or 50 mL Falcon tubes?

• Are you using multi-well plates?

2. Consider Sample Volume & Throughput

✔ Microcentrifuges handle 0.2 to 2.0 mL tubes and are great for small-scale prep.
✔ Benchtop centrifuges accommodate 15–50 mL tubes, ideal for routine lab work.
✔ Floor-standing models handle large volumes for high-throughput applications.
✔ Multichannel or plate rotors are essential for high-throughput screening.

💡 Tip: Choose a centrifuge with slightly more capacity than you currently need—you’ll grow into it.

3. Know the Difference Between RPM and RCF

• RPM (Revolutions Per Minute): Rotor speed

• RCF (Relative Centrifugal Force): The actual force applied to your samples

• RCF is more meaningful when comparing models—especially if separating small particles like RNA or proteins.

Look for centrifuges that allow you to input either value, or provide a conversion chart.

4. Rotor Type: Fixed-Angle vs Swing-Out

✅ Fixed-Angle Rotor

• Tubes held at a ~45° angle

• Faster separation, ideal for pelleting

• Compact and high-speed

✅ Swing-Out Rotor

• Tubes swing out to horizontal during spin

• Better layer separation, perfect for blood or density gradients

• Slower speeds but more uniform sedimentation

💡 Some centrifuges support multiple rotor types—check for rotor compatibility and adapters.

5. Do You Need Refrigeration?

✔ Refrigerated centrifuges maintain sample stability at 4°C or below.
✔ Ideal for enzymes, proteins, blood plasma, and sensitive reagents.
✔ Usually more expensive, but essential for temperature-sensitive applications.

💡 Consider a refrigerated microcentrifuge for compact cooling functionality.

6. Look for Key Features

When comparing models, focus on features that improve usability, safety, and maintenance:

• Digital RPM/RCF control

• Timer and soft brake

• Lid lock with safety shut-off

• Automatic imbalance detection

• Rotor recognition

• Compact footprint or stackable design

• Quiet operation

7. Best-Selling Centrifuge Brands at LabFriend

At LabFriend, we carry a curated range of centrifuges from trusted brands known for performance and durability:

• Thermo Scientific – Clinical and research-grade centrifuges with rotor flexibility

• Grant Instruments – Easy-to-use benchtop centrifuges with safety features

• Eppendorf – Market-leading microcentrifuges and refrigerated units

• OHAUS – Robust build quality and precise digital control

🔗 Compare centrifuge models at LabFriend

8. Maintenance and Calibration Considerations

A well-maintained centrifuge can last over a decade with regular use. Choose models with:

• Easy-access rotors for cleaning

• Serviceable motors and electronics

• Availability of spare parts and rotor replacements

• Optional calibration services (LabFriend can assist)

9. Budget and Long-Term Value

While price is important, don’t cut corners on essential features. Consider:

• Speed range and rotor compatibility

• Warranty and brand reputation

• Future scalability for expanding lab needs

💡 Refrigerated and high-speed models cost more upfront but offer greater flexibility.

Final Checklist: What to Look for in the Best Centrifuge

✅ Application-specific functionality
✅ Appropriate volume range
✅ Accurate speed and RCF control
✅ Rotor compatibility (fixed, swing-out, plate)
✅ Temperature control (if needed)
✅ Safety features
✅ Trusted brand and support

Final Thoughts

Choosing the best centrifuge for your lab doesn’t have to be overwhelming. By understanding your application needs, sample volumes, rotor preferences, and feature requirements, you can confidently invest in a unit that will deliver years of reliable performance.

At LabFriend, we stock clinical, research, benchtop, and refrigerated centrifuges from trusted global manufacturers, with fast Australia-wide delivery and expert support.

🔍 Need help choosing? Contact us
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